Samurai Jack - Obsessive Compulsive Personality Disorder (also known as the 'Perfectionist Personality Disorder' or 'Anankastic Personality Disorder' and not to be confused with an anxiety disorder, Obsessive Compulsive Disorder), Schizophrenia, PTSD, and Clinical Depression
Aku - Narcissistic Personality Disorder (Malignant Narcissism) and Kleptomania
The Emperor (Samurai Jack's strict, brave father and ruler of Japan) - Obsessive Compulsive Personality Disorder (also known as the 'Perfectionist Personality Disorder' or 'Anankastic Personality Disorder' and not to be confused with an anxiety disorder, Obsessive Compulsive Disorder)
The Empress (Samurai Jack's shy, submissive mother and the Emperor's wife) - Dependent Personality Disorder
Anguish (one of many forms of Inner Jack) - Borderline Personality Disorder (Petulant Borderline)
Apathy (one of many forms of Inner Jack) - Paranoid Personality Disorder
Care (one of many forms of Inner Jack) - PTSD
Bloodlust (one of many forms of Inner Jack) - Antisocial Personality Disorder (Sociopathy)
Mad Jack - Antisocial Personality Disorder (Sociopathy) and Intermittent Explosive Disorder
Baby (as an adult in the future) - Obsessive Compulsive Personality Disorder (also known as the 'Perfectionist Personality Disorder' or 'Anankastic Personality Disorder' and not to be confused with an anxiety disorder, Obsessive Compulsive Disorder, possibly)
Bear Bounty Hunter - Borderline Personality Disorder (Discouraged Borderline)
Cacciatore - Narcissistic Personality Disorder (Overt Narcissism)
Chritchellites - Antisocial Personality Disorder (Sociopathy)
Cronus - Antisocial Personality Disorder (Sociopathy)
Demongo - Narcissistic Personality Disorder (Malignant Narcissism)
DJ Stylbator - Narcissistic Personality Disorder (Cerebral Narcissism)
Dome of Doom Champions - Antisocial Personality Disorder (Sociopathy)
Dominator - Antisocial Personality Disorder (Psychopathy)
Fishman - Narcissistic Personality Disorder (Overt Narcissism)
The Gentleman - Antisocial Personality Disorder (Sociopathy)
Hillbilly Bounty Hunter - Antisocial Personality Disorder (Sociopathy)
Huntor - Antisocial Personality Disorder (Sociopathy)
I and Am - Antisocial Personality Disorder (Sociopathy)
Imakandi - Obsessive Compulsive Personality Disorder (also known as the 'Perfectionist Personality Disorder' or 'Anankastic Personality Disorder' and not to be confused with an anxiety disorder, Obsessive Compulsive Disorder)
Jack-Aku - Bipolar Disorder
Josephine Clench - Histrionic Personality Disorder
Jujunga - Antisocial Personality Disorder (Sociopathy)
Lava Monster - Obsessive Compulsive Personality Disorder (also known as the 'Perfectionist Personality Disorder' or 'Anankastic Personality Disorder' and not to be confused with an anxiety disorder, Obsessive Compulsive Disorder) and Clinical Depression
Lazarus-92 - Antisocial Personality Disorder (Sociopathy)
Minions of Aku - Antisocial Personality Disorder (Sociopathy)
Minions of Set - Antisocial Personality Disorder (Sociopathy)
Orc Army - Antisocial Personality Disorder (Sociopathy)
Pig Sheriff - Antisocial Personality Disorder (Sociopathy)
Scaramouche - Narcissistic Personality Disorder (Malignant Narcissism)
Short Mischievous Scientist - Narcissistic Personality Disorder (Cerebral Narcissism)
Spring - Antisocial Personality Disorder (Psychopathy)
The Black Mass (Aku's creator) - Antisocial Personality Disorder (Psychopathy)
The Creature - ADHD
The Demonic Spirit - Antisocial Personality Disorder (Psychopathy)
Gargoyle - Narcissistic Personality Disorder (Overt Narcissism)
The Scotsman - Intermittent Explosive Disorder and Obsessive Love Disorder
The Scotsman's Wife - Intermittent Explosive Disorder
The Sirens - Histrionic Personality Disorder
Wolf - Obsessive Compulsive Personality Disorder (also known as the 'Perfectionist Personality Disorder' or 'Anankastic Personality Disorder' and not to be confused with an anxiety disorder, Obsessive Compulsive Disorder)
Ashi - Intermittent Explosive Disorder
Ashi's Sisters - Antisocial Personality Disorder (Sociopathy)
The High Priestess - Antisocial Personality Disorder (Sociopathy)